Three Essays in Family Economics

Thesis advisor: Donald CoxThis dissertation contains three essays. It provides analysis on issues concerning about family economics. The first essay investigates issues about intergenerational transfer in China. Does parental support in China respond to low income of the elderly? Intergenerational transfers from adult children to their parents are thought to contribute a significant portion of old-age support in China. With a fast growing elder population and an increasing old-age dependency ratio, it is important to understand these transfers. This study investigates the determining factors of intergenerational transfers in China. This line of research is still lacking due to the scarcity of detailed household data. Past studies on private transfers in China could not differentiate between intergenerational versus intragenerational transfers. Using pilot data from the newly released China Health and Retirement Longitudinal Study (CHARLS), I found that around half of the sampled households received transfers from adult children and the amount of transfer is as much as two-thirds of household income per capita. Data also showed that poorer households are more likely to receive transfers. Data suggested that people in the poor province (Gansu) have a higher degree of dependence on adult children, as the source of providing old-age support and living arrangement. Seeing how private transfers are large, widespread, and responsive to income, the benefits from instituting appropriate public policy would likely accrue in part to younger generations by lessening their burden of familial support. The second essay examines the effect of social father on the well-being of out-of-wedlock children. Social fathers, defined as stepfathers or unrelated cohabiting romantic partners of biological mothers, have become more widespread as a result of the increasing out-of-wedlock childbearing. With more young children living with social fathers, it is important to understand the effect of social fathers on the well-being of children. Previous research focused more on such effect on older children or adolescents. Using data from the Fragile Families and Child Wellbeing Study (FFCWS), I find that children with social fathers scored around three points less in a cognitive ability test than children living only with biological mothers. I used the propensity score matching method to address the selection issue for which the child's mother self-selected into having a new partner. Social fathers will be more common because of the widespread of non-marital births. Any negative effect caused by the social fathers will affect a large portion of child population. The third essay evaluates the association between the timing of parenthood and the timing of retirement. Is late parenting associated with late retirement? The trend of parenthood timing is under drastic change. The birth rate for women aged 30-34 rose from 52.3 births per 1000 women in 1975 to 96.5 births per 1000 women in 2010 while the birth rate for women aged 20-24 went down from 113 births to 90 births per 1000 women during the same period. The children may still be very young when their parents enter their retirement age. In the Health and Retirement Study (HRS), 20% of respondents' children lived with them while nearly 30% of these children were below 18 years of age. Despite the potential importance of this issue, economists have not done much research on it. Using the HRS, this study found that parents who have their first child before or at age 30 retire earlier than parents who have their first child after age 30. This positive association holds for different sub-groups of the sample. With significant portion of people delaying their parenthood and a large group of people entering their retiring age, it is very important for policy makers and economists to understand how the timing of parenthood associates with the timing of retirement.Thesis (PhD) — Boston College, 2013.Submitted to: Boston College. Graduate School of Arts and Sciences.Discipline: Economics

LED lighting development for intelligent clothing

Author name used in this publication: K. W. E. ChengAuthor name used in this publication: Y. L. KwokAuthor name used in this publication: K. W. ChanAuthor name used in this publication: N. C. CheungAuthor name used in this publication: K. W. KwokVersion of RecordPublishe

Impact of target warhead and linkage vector on inducing protein degradation:comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds

The design of proteolysis-targeting chimeras (PROTACs) is a powerful small-molecule approach for inducing protein degradation. PROTACs conjugate a target warhead to an E3 ubiquitin ligase ligand via a linker. Here we examined the impact of derivatizing two different BET bromodomain inhibitors, triazolodiazepine JQ1 and the more potent tetrahydroquinoline I-BET726, via distinct exit vectors, using different polyethylene glycol linkers to VHL ligand VH032. Triazolodiazepine PROTACs exhibited positive cooperativities of ternary complex formation and were more potent degraders than tetrahydroquinoline compounds, which showed negative cooperativities instead. Marked dependency on linker length was observed for BET-degrading and cMyc-driven antiproliferative activities in acute myeloid leukemia cell lines. This work exemplifies as a cautionary tale how a more potent inhibitor does not necessarily generate more potent PROTACs and underscores the key roles played by the conjugation. The provided insights and framework for structure–activity relationships of bivalent degraders are anticipated to have wide future applicability

General study on piezoelectric transformer

Author name used in this publication: Cheng K. W. E.Author name used in this publication: Kwok K. W.Power Electronics Research Center, Department of Electrical EngineeringAuthor name used in this publication: Chan H.Refereed conference paper2004-2005 > Academic research: refereed > Refereed conference paperVersion of RecordPublishe

Modeling and analysis of piezoelectric transformer using multi-mesh loop matrix circuit under square-wave excitation conditions

K. W. Kwok, X. X. Wang and H. Chan, Department of Applied PhysicsAuthor name used in this publication: K. W. E. ChengAuthor name used in this publication: S. L. HoAuthor name used in this publication: K. W. KwokAuthor name used in this publication: H. ChanAuthor name used in this publication: X. D. XueRefereed conference paper2005-2006 > Academic research: refereed > Refereed conference paperVersion of RecordPublishe

Risk factors for infection or colonization by levofloxacin-resistant Streptococcus pneumoniae in Hong Kong

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Clinical and Pathological Findings in Women with Fabry Disease

Introduction. Fabry disease is a rare metabolic disorder caused by the genetic deficiency of the lysosomal hydrolase alpha-galactosidase A, located on chromosome X. Females with the defective gene are more than carriers and can develop a wide range of symptoms. Nevertheless, disease symptoms generally occur later and are less severe in women than in men. The enzyme deficiency manifests as a glycosphingolipidosis with progressive accumulation of glycosphingolipids and deposit of inclusion bodies in lysosomes giving a myelinlike appearance. Patients and Methods. Records of renal biopsies performed on adults from 1st January 2008 to 31st August 2011, were retrospectively examined at the Renal Pathology Laboratory. We retrieved biopsies diagnosed with Fabry disease and reviewed clinical and laboratory data and pathology findings. Results. Four female patients with a mean age of 49.3±4.5 (44-55) years were identified. The mean proteinuria was 0.75±0.3 g/24h (0.4-1.2) and estimated glomerular filtration rate (CKD EPI equation) was 71±15.7 ml/min/1.73m2 (48-83). Three patients experienced extra-renal organ involvement (cerebrovascular, cardiac, dermatologic, ophthalmologic and thyroid) with distinct severity degrees. Leukocyte α-GAL A activity was below normal range in the four cases but plasma and urinary enzymatic activity was normal. Light microscopy showed predominant vacuolisation of the podocyte cytoplasm and darkly staining granular inclusions on paraffin and plastic-embedded semi-thin sections. Electron microscopy showed in three patients the characteristic myelin-like inclusions in the podocyte cytoplasm and also focal podocyte foot process effacement. In one case the inclusions were also present in parietal glomerular cells, endothelial cells of peritubular capillary and arterioles. Conclusion. Clinical signs and symptoms are varied and can be severe among heterozygous females with Fabry disease. Intracellular accumulation of glycosphingolipids is a characteristic histologic finding of Fabry nephropathy. Since this disease is a potentially treatable condition, its early identification is imperative. We should consider it in the differential diagnosis of any patient presenting with proteinuria and/or chronic kidney disease, especially if there is a family history of kidney disease

Effects of risk assessment and management programme for hypertension on clinical outcomes and cardiovascular disease risks after 12 months: a population-based matched cohort study

Objectives: This study evaluated the effectiveness of a structured multidisciplinary risk assessment and management programme for patients with hypertension (RAMP-HT) who were managed in public primary care clinics but had suboptimal blood pressure (BP) control in improving BP, LDL-cholesterol (LDL-C) and predicted 10-year cardiovascular disease (CVD) risk after 12 months of intervention. Methods: A total of 10 262 hypertension patients with suboptimal BP despite treatment, aged less than 80 years and without existing CVD were enrolled in RAMP-HT between October 2011 and March 2012 from public general out-patient clinics in Hong Kong. Their clinical outcomes and predicted 10-year CVD risk were compared with a matched cohort of hypertension patients who were receiving usual care in general out-patient clinics without any RAMP-HT intervention by propensity score matching. Multivariable linear and logistic regressions were used to determine the independent effectiveness of RAMP-HT after adjusting for potential confounding variables. Results: Compared with the usual care group after 12 months, significantly greater proportions of RAMP-HT participants achieved target BP (i.e. BP 20%) (OR = 1.13, P < 0.01). RAMP-HT participants also had significantly greater reduction in predicted 10-year CVD risk by 0.44% (coefficient = -0.44, P < 0.01). Conclusion: The structured multidisciplinary RAMP-HT was more effective than usual care in achieving target BP, LDL-C and reducing predicted 10-year CVD risk in public primary care patients with suboptimal hypertension control after 12 months of intervention. A long-term follow-up should be conducted to confirm whether the improvement in clinical outcomes can be translated into actual reductions in CVD complications and mortalities and whether such approach is cost-effective.published_or_final_versio

The Effect of Social Fathers on the Cognitive Skills of Out-of-Wedlock Children

There are two competing views regarding the presence of social fathers on childrens’ cognitive ability: either the social father provides more financial need to the children or the mother with new partners may shift the focus away from the children. Previous research focused more on such effect on older children or adolescents and ignored the self-selection problem. We use data from the Fragile Families and Child Wellbeing Study (FFCWS), and a sample of younger children. Assuming that self-selection is based on observables and using ordinary least square, propensity score matching method (nonparametric methods), we find that children with social fathers scored around three points less in a cognitive ability test than children living only with biological mothers. The result remains the same when using a control-function analysis (parametric)

Systems dynamics in the community care pathway at the end-of-life: the Hong Kong experience

BACKGROUND: Since 2009, the HKWC-CGAT in collaboration with TWGHs JC C&A Home piloted the “EOL Program for RCHE in HKWC” program. The program offered 2 EoL care pathways on top of existing care framework: 1) AED pathway: residents remain in RCHE during last stage of life and stay there until very last moment of life; 2) FYKH pathway: resident be transferred to the hospital via expedite pathway at the last moment of life to receive hospice and palliative care until he/she passed away. The program has served 32 residents, 9 have chosen the AED pathway and two passed away peacefully in 2010. Success of this program highlights the need to examine interplaying factors in EoL care pathway and reflect on practical implications for quality EoL care. OBJECTIVE: To identify system factors that contributes to EoL care decision making and dignified EoL Care Pathways. METHOD: This is a qualitative study with individual interviews and focus groups conducted. Participants was …published_or_final_versio